A similar interaction between the T allele and body mass index was observed on the maximum blood pressure achieved during a treadmill exercise test (P<0.001). Subjects homozygous for the T allele had higher resting blood pressure levels than others (P<0.05). To determine whether this finding could be replicated, the ET1/C198 was genotyped in the Glasgow Heart Scan Study, a population-based study including 619 men and 663 women. However, a G/T polymorphism predicting an Lys/Asn change (ET1/C198) strongly interacted (P/=26 kg/m2), while no significant effect was observed in lean subjects (body mass index <26 kg/m2). The polymorphisms were not associated with myocardial infarction, nor did they contribute to blood pressure levels in the population at large.

Five polymorphisms were detected, which were genotyped in the ECTIM (Etude Cas-Témoin de l'Infarctus du Myocarde) Study, a multicenter study comparing 648 male patients who had survived a myocardial infarction and 760 population-based controls. The entire coding sequence and 1.4 kb of the 5' flanking region were screened. Our objective was to examine whether molecular variations at the endothelin-1 locus were involved in susceptibility to myocardial infarction and variation in blood pressure. There is accumulating evidence that endothelin-1 plays an important role in vascular pathophysiology. The similarities in risk factor patterns may indicate similarities in the biologic mechanisms underlying the two conditions. Significantly lower risks of preeclampsia and gestational hypertension were observed for women born outside Nordic countries and in association with maternal smoking and summer birth. Compared with underweight women (body mass index 29) had increased risks of both gestational hypertension (odds ratio = 4.85, 95% confidence interval 1.97-11.92) and preeclampsia (odds ratio = 5.19, 95% confidence interval 2.35-11.48). The positive associations between these variables and the risk of gestational hypertension were weaker and nonsignificant. The following risk factors were significantly associated with increased risk of preeclampsia: type 1 diabetes (odds ratio = 5.58, 95% confidence interval 2.72-11.43), gestational diabetes (odds ratio = 3.11, 95% confidence interval 1.61-6.00), and twin birth (odds ratio = 4.17, 95% confidence interval 2.30-7.55). Of these 10,666 women, 4.4% developed gestational hypertension, and 5.2% developed preeclampsia. The data were collected from The Swedish Medical Birth Register and include all nulliparas aged 34 years or less who gave birth at the University Hospital of Uppsala, Sweden, during 1987-1993.

The objective of this study was to evaluate and compare risk factor patterns in association with preeclampsia and gestational hypertension. Interaksi genotip CC/TC dan IMB menyebabkan resiko 6x lebih besar terhadap terjadinya HG. Hasil penelitian kami menunjukkan adanya hubungan yang signifikan antara CC genotip ET-1 dengan terjadinya HG dan IMB dengan terjadinya HG. Odd Ratio (OR) digunakan untuk menghitung resiko polimorfisme gen T/C 8002 ET-1, dan interaksinya dengan IMB terhadap kejadian hipertensi gestasional. Data yang ada diolah menggunakan Kruskall-Wallis dan Chi Square untuk melihat adanya perbedaan antara kedua grup. Pemeriksaan genotip gen ET-1 dilakukan menggunakan Polymerase Chain Reaction (PCR) dan Restricted Fragment Length Polymorphism (RFLP). Diagnosa HG ditegakkan apabila tekanan darah sistolik ≥140 mmHg atau tekanan darah diastolic ≥90 mmHg pada usia kehamilan >20 minggu, dimana sebelum kehamilan tekanan darah subyek tersebut normal dan tekanan darah kembali normal pada 12 minggu setelah melahirkan. Penelitian secara case control ini melibatkan 10 subyek pasien dengan HG dan 35 subyek dengan tekanan darah normal. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara polimorfisme gen T/C 8002 ET-1 dengan index massa tubuh terhadap terjadinya HG. Mengingat terbatasnya penelitian yang dilakukan tentang polimorfisme genotip yang berkaitan dengan HE, maka terbatas pula laporan tentang peranan gen ET-1 dengan HG. Interaksi antar gen ke gen dan interaksi gen dengan lingkungan memainkan peranan penting dalam patogenesis terjadinya hipertensi esensial (HE), dan mungkin juga pada HG.

Abstrak Hipertensi gestasional (HG) merupakan sebuah penyakit yang komplex, yang menyebabkan angka mortalitas yang tinggi pada ibu hamil di negara sedang berkembang dan negara belum berkembang.

Persamaan ic 8002a